Structural mechanism of inhibitor-resistance by ERK2 mutations
نویسندگان
چکیده
منابع مشابه
Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation
The structure of the active form of the MAP kinase ERK2 has been solved, phosphorylated on a threonine and a tyrosine residue within the phosphorylation lip. The lip is refolded, bringing the phosphothreonine and phosphotyrosine into alignment with surface arginine-rich binding sites. Conformational changes occur in the lip and neighboring structures, including the P+1 site, the MAP kinase inse...
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ژورنال
عنوان ژورنال: BIODESIGN
سال: 2021
ISSN: 2288-6982,2288-7105
DOI: 10.34184/kssb.2021.9.1.14